Gender differences low-density lipoprotein cholesterol reduction with PCSK9 inhibitors in real world patients

نویسندگان

چکیده

Abstract Background Monoclonal antibodies that inhibit the proprotein convertase subtilisin/kexin type 9 (PCSK9) reduce low-density lipoprotein cholesterol (LDLc) by 55%, regardless of baseline treatments, and are supposed to have a homogenous effect. We tested possible gender differences in large multicenter registry real-world patients treated with PCSK9 inhibitors. Methods Multicentre retrospective inhibitors from 14 different hospitals Spain. Before on-treatment LDLc was recorded as well medical clinical indication features. Results A total 562 were analysed, mean age 60.2 (9.6) years 79.2% males. Most frequent for inhibitor treatment established cardiovascular disease (CVD) >100 mg/dl (58.1%) followed familial hypercholesterolemia (23.4%) statin intolerance (18.5%). Indications other than CVD more women (53.3% vs. 39.1%; p=0.03). Women frequently ezetimibe (67.5% 50.6%; p=0.001) before treatment; although no use observed (78.6% 83.6%; p=0.93) whole cohort it significantly lower coronary heart (91.4% 98.9%; p=0.005). 148.7 (50.1) higher men (160.3 (59.3) 145.6 (47.0); Evolocumab initiated 318 (56.6%) patients; 229 (40.7%) alirocumab 75 mg 15 (2.7%) 150 mg. No drug or dose observed. Median time second blood determination 187.5 (IQR 101–242) days. Mean 66.7 (46.4) also (84.4 (58.6) 61.9 (41.3); p<0.001). reduction 54.7% but compared (57.0% 46.1%; p=0.0003). Higher reductions 2 indications (57.1% 47.3%; p=0.002). Moreover, vs among (58.9% 48.0%; p=0.04) Conclusions This multicentre highlights significant reduction. FUNDunding Acknowledgement Type funding sources: None.

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ژورنال

عنوان ژورنال: European Heart Journal

سال: 2021

ISSN: ['2634-3916']

DOI: https://doi.org/10.1093/eurheartj/ehab724.2589